Reader Kevin Liu2020-7-29 asked on his face: Hello Professor
, I am here to complain about you again. I have seen people on the Internet that I advocate taking NAC as healthy foods. I'll give you a second explanation if you have time. Thank you for your gratitude
After reading this article, I replied: "This article is roughly correct, but there are two serious errors. It does not explicitly advocate eating, but there are several other websites that explicitly advocate eating. I have published an article about NAC."
The author of this article is Pharmacist Chen Siting, no date, and the title is: Detoxification New Hope, cetathiamine (GSH) predrug-acetylcysteine. I have sorted out several of its key points as follows:
1. Glutathione (simple GSH) is one of the most important elements in the liver detoxification process.2. Cathedhiamine is a short-linked peptide (small segments of protein). When taken orally to the stomach, it will be decomposed by gastric acid and pepsin that specifically breaks down protein.
3.Acetyl Cystein (simplified by NAC) can quickly and efficiently transform into chathicinic acid in the human body.
4.NAC is an excellent natural and healthy product, but because NAC is a short chain protein of ….
The first point above is correct, the second point is some disputes (which will be explained later), and the third point has two errors: (1) N-Acetyl Cystein is an error, and it should be N-Acetyl Cysteine for (2) "Transformation into Cathylate" is also an error, because NAC is only converted into Cysteine, and then Cysteine is used to synthesize Cathylate. The fourth point is the wrong deduction, because NAC is not natural, nor is it protein, but artificially synthesized amino acids (acetylated cysteine).
Reader William Chen used the website’s “Contact Me” on August 20, 2020 to inquire:
Professor Lin, safe! When I saw your book on the bookstore shelf, I immediately finished reading the first two books. Actually, I benefited a lot. Many of the nutritional knowledge we believe are really wrong! A friend came to mention "glutathione", and mentioned that there are many benefits, such as detoxification, nourishing and beauty, whitening, liver protection, sleeping, cancer remedy, and food additives … like a magic medicine! I was puzzled and curious, so I went online to search, and the results surprised me again. There were so many articles, products and research on "glutathione". Since I don't have a professional background in the field of biochemical, I would like to ask you for your professional scientific opinions. Especially after I carefully read the article, I found that some people said that GSH cannot be obtained and absorbed through diet, and some people said that it can be completely absorbed, so there is no consensus! Another key question is: Do we really need to "replenish" GSH? Therefore, I would like to ask Professor Lin to help resolve the doubts, thank you!It's true that the online one is to say cetathionine (cetathione) is a magical medicine, and it is impossible. Some people on the online one say it cannot be taken through diet (such as the article by Chen Siting Pharmacist mentioned above), but some people say it can. The article published by
William Chen provided by the Internet link was published on September 3, 2018. The title is "Can oral cetathione be absorbed by the body? 》. This pharmacist has provided 5 research papers to support his commentary on "Oral cetathione can be absorbed by the body" (Published in 2102, 2014, 2015, 2017). But the problem is that most research papers do not believe that oral cetathione can be absorbed by the body, and the papers published in recent years do not believe that oral cetathione can be absorbed by the body. For example, this article published in 2019: The absorptive effects of orobuccal non-liposomal nano-sized glutathione on blood glutathione parameters in healthy individuals: A pilot Study (Absorption effect of oral non-lipid nanotathione on cetathione parameters in healthy individual blood: a preliminary study).
Also, two of the 5 articles provided by this pharmacist believe that oral cetathione can whiten the skin, but this discussion is highly doubtful, such as the following three articles:
2016: Glutathione as a skin whitening agent: Facts, myths, evidence and controversies2018: Glutathione for skin lightening: a regnant myth or evidence-based Verity? (Glutathione is used to whiten the skin: is it a myth or based on evidence of authenticity?)
2020: Systemic Glutathione as a Skin-Whitening Agent in Adult
Some health medical websites with larger scale and better reputations also say that oral gratathione is not effective, such as WebMD and Healthline.
So, this pharmacist probably chose several different articles to highlight his differences from the public. Unfortunately, these different articles have not been widely recognized by the medical community.
As for the "Do we really need to "replenish" GSH by reader William Chen? 》, the answer is no, because GSH was originally synthesized by our body. If there is really a saying in "GSH Deficiency", then GSH is needed instead of oral administration.
Original text: cetathiamine, acetylcysteine, defect information